| Package | Dosage | Price | Price per Dose | |
|---|---|---|---|---|
| Dosage: 2,5mg | ||||
| 360 pill | 2,5mg | £217.75 | £0.60 | |
| 180 pill | 2,5mg | £117.16 | £0.65 | |
| 120 pill | 2,5mg | £84.02 | £0.70 | |
| 90 pill | 2,5mg | £68.63 | £0.76 | |
| 60 pill | 2,5mg | £49.70 | £0.83 | |
| 30 pill | 2,5mg | £29.58 | £0.98 | |
| Dosage: 5mg | ||||
| 360 pill | 5mg | £191.72 | £0.53 | |
| 180 pill | 5mg | £111.24 | £0.62 | |
| 120 pill | 5mg | £78.10 | £0.65 | |
| 90 pill | 5mg | £61.53 | £0.69 | |
| 60 pill | 5mg | £42.59 | £0.71 | |
| 30 pill | 5mg | £24.84 | £0.83 | |
Glibenclamide Description
Overview of Glibenclamide
Glibenclamide, also known as glyburide in some regions, is a widely used medication for managing type 2 diabetes mellitus. It belongs to the sulfonylurea class of drugs, which work by stimulating the pancreas to produce more insulin. This increase in insulin helps to lower blood sugar levels, making it an effective choice for patients who need additional help controlling their glucose. The medication is typically prescribed alongside diet and lifestyle changes to improve overall blood sugar management.
Pharmacological Action and Benefits
Glibenclamide works by binding to specific receptors on pancreatic beta cells. This binding inhibits potassium channels, leading to cell depolarization. As a result, calcium channels open, prompting the release of insulin. It provides a relatively quick onset of action and offers prolonged blood sugar control. Many users find it effective in reducing post-meal glucose spikes and fasting blood sugar levels, helping to maintain better overall glycemic control.
Usage and Dosage
The medication is generally taken orally, once or twice daily, depending on the physician’s instructions. The dosage varies based on individual factors such as the severity of diabetes, age, kidney function, and response to the medication. It’s important to follow the prescribed dosage closely and not to adjust it without medical guidance. Regular monitoring of blood glucose levels is essential to ensure effectiveness and to minimize potential side effects.
Possible Side Effects and Precautions
While Glibenclamide is effective for many, it can cause side effects in some users. Common adverse reactions include hypoglycemia, which can manifest as sweating, dizziness, tremors, or weakness. Allergic reactions like skin rashes are also possible. Some may experience gastrointestinal discomfort or weight gain. Patients with liver or kidney problems need to use this medication with caution, as these conditions can affect how the drug is metabolized and cleared from the body. It is vital to inform your healthcare provider about all existing health issues and medications to avoid interactions.
Considerations for Safe Use
Proper diet and regular physical activity greatly enhance Glibenclamide’s effectiveness. Patients should avoid excessive alcohol consumption, as it can increase the risk of hypoglycemia. It is also important to carry quick sources of sugar, like glucose tablets or candies, in case of low blood sugar episodes. Regular medical check-ups and blood tests are necessary to monitor the response to therapy and prevent potential complications. Never skip doses or double up on medication without medical advice.
Conclusion
Glibenclamide remains a dependable option for managing type 2 diabetes, especially for patients who require additional insulin secretion support. Its proven efficacy and long history of use make it a valuable part of personalized diabetes therapy. However, its use demands careful attention to dosing, monitoring, and lifestyle factors to maximize benefits and minimize risks. Consulting a healthcare professional is essential for safe and effective treatment with Glibenclamide.